Liquid and semisolid SLN dispersions for topical application: rheological characterization.

@article{Lippacher2004LiquidAS,
  title={Liquid and semisolid SLN dispersions for topical application: rheological characterization.},
  author={A Lippacher and Rainer Helmut M{\"u}ller and Karsten M{\"a}der},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2004},
  volume={58 3},
  pages={561-7}
}
Aqueous dispersions of solid lipid nanoparticles (SLN) are promising drug carrier systems for topical application. A drawback, however, is the need of incorporating the SLN dispersion in commonly used dermal carriers (creams, gels) to obtain the required semisolid consistency for dermal application. This study describes the production of SLN dispersions having the desired semisolid consistency by a one-step process. Physical characterization of these systems in terms of particle size and… CONTINUE READING
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