Liquid Chromatographic Resolution of the Enantiomers of Metoprolol and Carvedilol in Pharmaceutical Formulations by use of Marfey’s Reagent and its Variants

@article{Bhushan2010LiquidCR,
  title={Liquid Chromatographic Resolution of the Enantiomers of Metoprolol and Carvedilol in Pharmaceutical Formulations by use of Marfey’s Reagent and its Variants},
  author={R. Bhushan and C. Agarwal},
  journal={JPC – Journal of Planar Chromatography – Modern TLC},
  year={2010},
  volume={23},
  pages={335 - 338}
}
  • R. Bhushan, C. Agarwal
  • Published 2010
  • Chemistry
  • JPC – Journal of Planar Chromatography – Modern TLC
A simple and rapid method has been established for indirect separation of the enantiomers of (R,S)-metoprolol and (R,S)-carvedilol by reversed-phase TLC. Beta blockers derivatized with 1-fluoro-2,4-dinitrophenyl-5-l-alanine amide (Marfey’s reagent, FDNP-l-Ala-NH2) and its six structural variants (FDNP-l-Phe-NH2, FDNP-l-Val-NH2, FDNP-l-Pro-NH2, FDNP-l-Leu-NH2, FDNP-l-Met-NH2, and FDNP-d-Phg-NH2) were spotted on precoated plates. (R,S)- Metoprolol and (R,S)-carvedilol were isolated from… Expand
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