Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

@inproceedings{Ambadipudi2017LiquidliquidPS,
  title={Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau},
  author={Susmitha Ambadipudi and Jacek Biernat and D Riedel and Eckhard Mandelkow and Markus Zweckstetter},
  booktitle={Nature Communications},
  year={2017}
}
The protein Tau aggregates into tangles in the brain of patients with Alzheimer’s disease. In solution, however, Tau is intrinsically disordered, highly soluble, and binds to microtubules. It is still unclear what initiates the conversion from an innocuous phase of high solubility and functionality to solid-like neurotoxic deposits. Here, we show that the microtubule-binding repeats of Tau, which are lysine-rich, undergo liquid–liquid phase separation in solution. Liquid–liquid demixing causes… CONTINUE READING
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