Liprin-α controls stress fiber formation by binding to mDia and regulating its membrane localization.

@article{Sakamoto2012LiprinCS,
  title={Liprin-α controls stress fiber formation by binding to mDia and regulating its membrane localization.},
  author={Satoko Sakamoto and Toshimasa Ishizaki and Kentaro Okawa and Sadanori Watanabe and Takatoshi Arakawa and Naoki Watanabe and Shuh Narumiya},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 1},
  pages={
          108-20
        }
}
Regulation of the actin cytoskeleton is crucial for cell morphology and migration. mDia is an actin nucleator that produces unbranched actin filaments downstream of Rho. However, the mechanisms by which mDia activity is regulated in the cell remain unknown. We pulled down Liprin-α as an mDia-binding protein. The binding is mediated through the central region of Liprin-α and through the N-terminal Dia-inhibitory domain (DID) and dimerization domain (DD) of mDia. Liprin-α competes with Dia… CONTINUE READING

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