Lipoxygenase products increase monocyte adhesion to human aortic endothelial cells.

@article{Patricia1999LipoxygenasePI,
  title={Lipoxygenase products increase monocyte adhesion to human aortic endothelial cells.},
  author={Mary Kim Patricia and J A Kim and Christina M Harper and P T Shih and Judith A. Berliner and Rama Natarajan and Jerry L Nadler and Catherine C. Hedrick},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1999},
  volume={19 11},
  pages={2615-22}
}
The development of atherosclerosis is accelerated in individuals with type 2 diabetes. Adhesion of monocytes to the vascular endothelium is a key initial step in atherogenesis. We have previously shown that monocyte adhesion to human aortic endothelial cells (HAECs) cultured long-term in high-glucose medium (25 mmol/L, 2 passages) is increased compared with cells grown in normal glucose (5 mmol/L). One potential mechanism for increased monocyte adhesion to HAECs under hyperglycemic conditions… CONTINUE READING
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