Lipoxygenase metabolites in the rat gastric microvascular response to intragastric ethanol.

@article{Yonei1989LipoxygenaseMI,
  title={Lipoxygenase metabolites in the rat gastric microvascular response to intragastric ethanol.},
  author={Yoshikazu Yonei and Paul H. Guth},
  journal={Gastroenterology},
  year={1989},
  volume={97 2},
  pages={304-12}
}
The role of lipoxygenase metabolites in ethanol-induced gastric mucosal injury and submucosal microvascular change in the rat was studied by in vivo microscopy. Intragastric ethanol-instillation caused marked submucosal venular constriction, dilatation of small arterioles, and corpus mucosal gross lesion formation. The venoconstriction was greater in the lesion than in the nonlesion area. Intragastric pretreatment with either BW755C, a lipoxygenase inhibitor, or Rioprostil, a synthetic… CONTINUE READING

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