Lipoxygenase metabolism of arachidonic acid in brain.

  title={Lipoxygenase metabolism of arachidonic acid in brain.},
  author={Sunday A. Adesuyi and C S Cockrell and Daniel Gamache and Earl F. Ellis},
  journal={Journal of neurochemistry},
  volume={45 3},
When blood-free mouse brain slices were incubated with exogenous radiolabeled arachidonic acid, gas chromatography/mass spectrometry confirmed that the major radioactive lipoxygenase enzyme product of arachidonic acid was 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE), with lesser amounts of 5-hydroxy-5,6,8,11,14-eicosatetraenoic acid and 15-hydroxy-5,8,11,13-eicosatetraenoic acid. When 12-[2H]HETE was used to measure endogenous 12-HETE in brain tissue frozen with liquid nitrogen, the… CONTINUE READING

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