Lipoxygenase metabolism of arachidonic acid in brain.

  title={Lipoxygenase metabolism of arachidonic acid in brain.},
  author={Sunday A. Adesuyi and C S Cockrell and Daniel Gamache and Earl F. Ellis},
  journal={Journal of neurochemistry},
  volume={45 3},
When blood-free mouse brain slices were incubated with exogenous radiolabeled arachidonic acid, gas chromatography/mass spectrometry confirmed that the major radioactive lipoxygenase enzyme product of arachidonic acid was 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE), with lesser amounts of 5-hydroxy-5,6,8,11,14-eicosatetraenoic acid and 15-hydroxy-5… CONTINUE READING