Lipoxygenase-mediated secretory effect of canatoxin the toxic protein from Canavalia ensiformis seeds.

Abstract

Canatoxin was shown to induce serotonin release from rabbit platelets and rat brain synaptosomes, as well as to release insulin from isolated pancreatic islets. All these effects were dose-dependent and were inhibited by lipoxygenase inhibitors, such as nordihydroguaiaretic acid and esculetin, but not by indomethacin, a cyclooxygenase inhibitor. The data… (More)

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@article{BarjaFidalgo1991LipoxygenasemediatedSE, title={Lipoxygenase-mediated secretory effect of canatoxin the toxic protein from Canavalia ensiformis seeds.}, author={Cristina Barja-Fidalgo and J. A. Guimar{\~a}es and Celia R. R. S. Carlini}, journal={Toxicon : official journal of the International Society on Toxinology}, year={1991}, volume={29 4-5}, pages={453-9} }