Lipoxygenase and prostaglandin G/H synthase cascades in cardiovascular disease.

@article{Zhao2006LipoxygenaseAP,
  title={Lipoxygenase and prostaglandin G/H synthase cascades in cardiovascular disease.},
  author={Lei Zhao and Tilo Grosser and Susanne Fries and Leena Kadakia and He Wang and Jonathan C Zhao and Robert Falotico},
  journal={Expert review of clinical immunology},
  year={2006},
  volume={2 4},
  pages={649-58}
}
The 12/15-lipoxygenase (LO) cascade governs the generation of 12-hydroperoxy-eicosatetraenoic acid (HPETE) and 15-HPETE from arachidonic acid. The 5-LO pathway plays a fundamental role in the biosynthesis of leukotrienes, essential inflammatory lipid mediators. Cyclooxygenase (COX)-1 and -2 biosynthetic pathways are responsible for prostaglandin and… CONTINUE READING