Lipoxins stimulate prostacyclin generation by human endothelial cells.

  title={Lipoxins stimulate prostacyclin generation by human endothelial cells.},
  author={Mark E. Brezinski and Michael A. Gimbrone and K C Nicolaou and Charles N Serhan},
  journal={FEBS letters},
  volume={245 1-2},
Cultured human umbilical endothelial cells were incubated with lipoxins and their ability to generate prostacyclin (PGI2) was assessed and compared to that induced by either leukotriene C4 or an ionophore of divalent cations (A-23,187). When exposed to either lipoxin A4, lipoxin B4, or 7-cis,11-trans-lipoxin A4, endothelial cells generated prostacyclin detected as 6-keto-PGF1 alpha. Of the lipoxins examined, 7-cis,11-trans-lipoxin A4 proved to be the most effective with PGI2 production twice… CONTINUE READING


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