Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis.

@article{Gewirtz2002LipoxinAA,
  title={Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis.},
  author={Andrew T. Gewirtz and Lauren S. Collier-Hyams and Andrew N. Young and Torsten F Kucharzik and William J. Guilford and John F. Parkinson and Ifor R Williams and Andrew S. Neish and James L. Madara},
  journal={Journal of immunology},
  year={2002},
  volume={168 10},
  pages={5260-7}
}
The anti-inflammatory eicosanoid lipoxin A(4) (LXA(4)), aspirin-triggered 15-epi-LXA(4), and their stable analogs down-regulate IL-8 secretion and subsequent recruitment of neutrophils by intestinal epithelia. In an effort to elucidate the mechanism by which these lipid mediators modulate cellular proinflammatory programs, we surveyed global epithelial gene expression using cDNA microarrays. LXA(4) analog alone did not significantly affect expression of any of the >7000 genes analyzed. However… CONTINUE READING

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