Lipoxin A₄ and benzo-lipoxin A₄ attenuate experimental renal fibrosis.

@article{Brgeson2011LipoxinAA,
  title={Lipoxin A₄ and benzo-lipoxin A₄ attenuate experimental renal fibrosis.},
  author={Emma B{\"o}rgeson and Neil G Docherty and Madeline Murphy and Karen Rodgers and Aidan Ryan and Tim P O'Sullivan and Patrick J Guiry and Roel Goldschmeding and Debra F. Higgins and Catherine Godson},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2011},
  volume={25 9},
  pages={2967-79}
}
Unresolved inflammation underlies the development of fibrosis and organ failure. Here, we investigate the potential of the proresolving eicosanoid lipoxinA₄ (LXA₄) and its synthetic analog benzo-LXA₄ to prophylactically modulate fibrotic and inflammatory responses in a model of early renal fibrosis, unilateral ureteric obstruction (UUO). Male Wistar rats (Animalia, Chordata, Rattus norvegicus) were injected intravenously with vehicle (0.1% ethanol), LXA₄ (45 μg/250-g rat), or benzo-LXA₄ (15 μg… CONTINUE READING
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