Lipoxin A(4) analogues inhibit leukocyte recruitment to Porphyromonas gingivalis: a role for cyclooxygenase-2 and lipoxins in periodontal disease.

@article{Pouliot2000LipoxinAA,
  title={Lipoxin A(4) analogues inhibit leukocyte recruitment to Porphyromonas gingivalis: a role for cyclooxygenase-2 and lipoxins in periodontal disease.},
  author={Marc Pouliot and Clary B Clish and Nicos A Petasis and Thomas E Van Dyke and Charles N Serhan},
  journal={Biochemistry},
  year={2000},
  volume={39 16},
  pages={4761-8}
}
The potential involvement of the inducible cyclooxygenase isoform (COX-2) and the role of novel lipid mediators were investigated in the pathogenesis of periodontal disease. Crevicular fluids from localized juvenile periodontitis (LJP) patients contained prostaglandin (PG)E(2) and 5-lipoxygenase-derived products, leukotriene B(4), and the biosynthesis interaction product, lipoxin (LX)A(4). Neutrophils from peripheral blood of LJP patients, but not from asymptomatic donors, also generated LXA(4… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 69 extracted citations

Similar Papers

Loading similar papers…