Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation.

@article{McMahon2002LipoxinLA,
  title={Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation.},
  author={Blaithin A McMahon and Derick Mitchell and Richard Shattock and Finian M Martin and Hugh R. Brady and Catherine Godson},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2002},
  volume={16 13},
  pages={1817-9}
}
The lipoxygenase-derived leukotrienes (LTs) are important proinflammatory lipid mediators. Lipoxins (LXs), more recently described lipoxygenase products, modulate many proinflammatory actions of LTs and have impressive proresolution properties. Mesangial cell (MC) proliferation is a central event in the pathogenesis of glomerulonephritis. LTD4-induced proliferation of mesangial cells is modulated by LXA4. Here, we demonstrate that LXA4 inhibits PDGF- and LTD4-stimulated proliferation through… CONTINUE READING
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