Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62/sequestosome 1 phosphorylation.

@article{Cho2017LipotoxicityIH,
  title={Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62/sequestosome 1 phosphorylation.},
  author={Chun-Seok Cho and H. Park and Allison Ho and Ian A. Semple and Boyoung Kim and Insook Jang and Haeli Park and Shannon M. Reilly and Alan R. Saltiel and Jun Hee Lee},
  journal={Hepatology},
  year={2017}
}
Obesity commonly leads to hepatic steatosis, which often provokes lipotoxic injuries to hepatocytes that cause nonalcoholic steatohepatitis (NASH). NASH, in turn, is associated with the accumulation of insoluble protein aggregates that are composed of ubiquitinated proteins and ubiquitin adaptor p62/sequestosome 1 (SQSTM1). Formation of p62 inclusions in… CONTINUE READING