Lipotoxicity contributes to endothelial dysfunction: A focus on the contribution from ceramide

Abstract

Cardiovascular complications are the leading causes of morbidity and mortality in individuals with obesity, type 2 diabetes mellitus (T2DM), and insulin resistance. Complications include pathologies specific to large (atherosclerosis, cardiomyopathy) and small (retinopathy, nephropathy, neuropathy) vessels. Common among all of these pathologies is an… (More)
DOI: 10.1007/s11154-012-9235-3

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