Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus

@article{Biden2014LipotoxicER,
  title={Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus},
  author={Trevor J Biden and Ebru Boslem and Kwan Yi Chu and Nancy Sue},
  journal={Trends in Endocrinology & Metabolism},
  year={2014},
  volume={25},
  pages={389-398}
}
Failure of the unfolded protein response (UPR) to maintain optimal folding of pro-insulin in the endoplasmic reticulum (ER) leads to unresolved ER stress and β cell death. This contributes not only to some rare forms of diabetes, but also to type 2 diabetes mellitus (T2DM). Many key findings, elaborated over the past decade, are based on the lipotoxicity model, entailing chronic exposure of β cells to elevated levels of fatty acids (FAs). Here, we update recent progress on how FAs initiate ER… CONTINUE READING

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