Liposphere Local Anesthetic Timed-Release for Perineural Site Application

  title={Liposphere Local Anesthetic Timed-Release for Perineural Site Application},
  author={David B. Masters and Abraham J. Domb},
  journal={Pharmaceutical Research},
Purpose. This investigation determines the drug delivery capacity of Lipospheres, which are drug-containing solid-filled vesicles made of triglyceride with a phospholipid outer covering, to release local anesthetic in vitro and to produce sustained peripheral nerve block in vivo. Methods. The local anesthetic, bupivacaine, was loaded into Lipospheres in several dosage forms, characterized, and measured for in vitrorelease. In rats, Lipospheres were administered into a large space between muscle… CONTINUE READING
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