Liposomes radiolabeled with 159Gd-DTPA-BMA: preparation, physicochemical characterization, release profile and in vitro cytotoxic evaluation.

@article{Soares2011LiposomesRW,
  title={Liposomes radiolabeled with 159Gd-DTPA-BMA: preparation, physicochemical characterization, release profile and in vitro cytotoxic evaluation.},
  author={Daniel Cr{\'i}stian Ferreira Soares and M{\^o}nica Cristina de Oliveira and Raquel Gouv{\^e}a dos Santos and Margareth Spangler Andrade and Jos{\'e} M{\'a}rio Carneiro Vilela and Valbert Nascimento Cardoso and Gilson Andrade Ramaldes},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2011},
  volume={42 5},
  pages={
          462-9
        }
}
The present work describes the preparation, labeling, physicochemical characterization, and in vitro cytotoxic evaluation of long circulating pH-sensitive liposomes containing (159)Gd-DTPA-BMA. These liposomes were successfully obtained and submitted to neutron irradiation for gadolinium labeling. Their size, distribution, and homogeneity were determined by photon correlation spectroscopy, while their zeta potential was determined by laser Doppler anemometry. The morphology and structural… CONTINUE READING

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