Liposomes for phospholipase A2 triggered siRNA release: preparation and in vitro test.

@article{Foged2007LiposomesFP,
  title={Liposomes for phospholipase A2 triggered siRNA release: preparation and in vitro test.},
  author={Camilla Foged and Hanne Moerck Nielsen and Sven Frokjaer},
  journal={International journal of pharmaceutics},
  year={2007},
  volume={331 2},
  pages={
          160-6
        }
}

• Camilla Foged, Hanne Moerck Nielsen, Sven Frokjaer
• Published 2007 in International journal of pharmaceutics

Small interfering RNA (siRNA) is potent and highly specific for gene silencing. However, for therapeutic applications, delivery systems are required to protect siRNA from degradation, to enhance cellular uptake and for site-specific delivery. We used a double emulsion technique to encapsulate siRNA into stealth liposomes (SL) to increase entrapment efficiency compared to passive encapsulation. SL are designed for localized, active release of siRNA by secretory phosholipase A(2) (sPLA(2)). sPLA… CONTINUE READING

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