Liposomes for phospholipase A2 triggered siRNA release: preparation and in vitro test.

@article{Foged2007LiposomesFP,
  title={Liposomes for phospholipase A2 triggered siRNA release: preparation and in vitro test.},
  author={Camilla Foged and Hanne Moerck Nielsen and Sven Frokjaer},
  journal={International journal of pharmaceutics},
  year={2007},
  volume={331 2},
  pages={
          160-6
        }
}
Small interfering RNA (siRNA) is potent and highly specific for gene silencing. However, for therapeutic applications, delivery systems are required to protect siRNA from degradation, to enhance cellular uptake and for site-specific delivery. We used a double emulsion technique to encapsulate siRNA into stealth liposomes (SL) to increase entrapment efficiency compared to passive encapsulation. SL are designed for localized, active release of siRNA by secretory phosholipase A(2) (sPLA(2)). sPLA… CONTINUE READING
Highly Cited
This paper has 24 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

PEGylation improves the receptor-mediated transfection efficiency of peptide-targeted, self-assembling, anionic nanocomplexes.

Journal of controlled release : official journal of the Controlled Release Society • 2014
View 1 Excerpt