Liposomes as targeted drug delivery systems in the treatment of breast cancer.

@article{Sharma2006LiposomesAT,
  title={Liposomes as targeted drug delivery systems in the treatment of breast cancer.},
  author={Gaurav Sharma and Samah Anabousi and Christina Ehrhardt and M N V Ravi Kumar},
  journal={Journal of drug targeting},
  year={2006},
  volume={14 5},
  pages={301-10}
}
Solid tumors such as breast cancer have historically provided many challenges to anti-cancer therapy. Therapeutic hurdles to drug penetration in solid tumors include heterogeneous vascular supply and high interstitial pressures within tumor tissue, particularly in necrotic zones, lower pH and presence of leaky vasculature leading to reduced therapeutic response. Liposome based drug delivery systems offer the potential to enhance the therapeutic index of anti-cancer agents, either by increasing… CONTINUE READING

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