Liposomes and hyperthermia in mice: increased tumor uptake and therapeutic efficacy of doxorubicin in sterically stabilized liposomes.

@article{Huang1994LiposomesAH,
  title={Liposomes and hyperthermia in mice: increased tumor uptake and therapeutic efficacy of doxorubicin in sterically stabilized liposomes.},
  author={S K Huang and Paul R. Stauffer and Keelung Hong and Jian Wei Guo and Theodore L. Phillips and Aihua Huang and Demetrios Papahadjopoulos},
  journal={Cancer research},
  year={1994},
  volume={54 8},
  pages={
          2186-91
        }
}
We have shown that sterically stabilized (Stealth) liposomes (SL), can accumulate in the extracellular space within tumors, and may improve pharmacokinetics and therapeutic efficacy of encapsulated doxorubicin (SL-DOX). When SL-DOX were incubated in vitro at different temperatures with 50% bovine serum, approximately 20% of the encapsulated DOX was released at 42 degrees C within 1 min, compared with less than 1% DOX released at 37 degrees C. In vivo, mice were implanted s.c. with C-26 colon… CONTINUE READING

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