Liposomes Combined an Integrin αvβ3-Specific Vector with pH-Responsible Cell-Penetrating Property for Highly Effective Antiglioma Therapy through the Blood-Brain Barrier.

@article{Shi2015LiposomesCA,
  title={Liposomes Combined an Integrin αvβ3-Specific Vector with pH-Responsible Cell-Penetrating Property for Highly Effective Antiglioma Therapy through the Blood-Brain Barrier.},
  author={Kairong Shi and Yang Long and Chaoqun Xu and Yang Wang and Yue Qiu and Qianwen Yu and Yayuan Liu and Qianyu Zhang and Huile Gao and Zhirong Zhang and Qin He},
  journal={ACS applied materials & interfaces},
  year={2015},
  volume={7 38},
  pages={
          21442-54
        }
}
  • Kairong Shi, Yang Long, +8 authors Qin He
  • Published 2015
  • Medicine, Materials Science
  • ACS applied materials & interfaces
  • Glioma, one of the most common aggressive malignancies, has the highest mortality in the present world. Delivery of nanocarriers from the systemic circulation to the glioma sites would encounter multiple physiological and biological barriers, such as blood-brain barrier (BBB) and the poor penetration of nanocarriers into the tumor. To circumvent these hurdles, the paclitaxel-loaded liposomes were developed by conjugating with a TR peptide (PTX-TR-Lip), integrin αvβ3-specific vector with pH… CONTINUE READING

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