Liposome preparation using a hollow fiber membrane contactor--application to spironolactone encapsulation.

  title={Liposome preparation using a hollow fiber membrane contactor--application to spironolactone encapsulation.},
  author={Abdallah Laouini and Chiraz Jaafar-Maalej and Souad Sfar and Catherine Charcosset and Hatem Fessi},
  journal={International journal of pharmaceutics},
  volume={415 1-2},
In this study, we present a novel liposome preparation technique suitable for the entrapment of pharmaceutical and cosmetic agents. This new method uses a membrane contactor in a hollow fiber configuration. In order to investigate the process, key parameters influence on the liposome characteristics was studied. It has been established that the vesicle size distribution decreased with the organic phase pressure decrease, the phospholipid concentration decreases and the aqueous to organic phase… CONTINUE READING


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