Liposome-mediated modulation of multidrug resistance in human HL-60 leukemia cells.

@article{Rahman1992LiposomemediatedMO,
  title={Liposome-mediated modulation of multidrug resistance in human HL-60 leukemia cells.},
  author={Aquilur Rahman and Syed Rafat Husain and Javed Ather Siddiqui and Monika Verma and Michael Agresti and Medical Center and Ahmad R. Safa and Robert I Glazer},
  journal={Journal of the National Cancer Institute},
  year={1992},
  volume={84 24},
  pages={1909-15}
}
BACKGROUND Multidrug resistance (MDR) is a major obstacle in cancer treatment. Resistance of cultured tumor cells to major classes of cytotoxic drugs is frequently due to expression of a plasma membrane P-glycoprotein encoded by MDR genes. We have demonstrated that liposome-encapsulated doxorubicin is more toxic than the free drug and that it modulates MDR in Chinese hamster LZ cells and human colon cancer cells. PURPOSE To investigate further the association between expression of P… CONTINUE READING