Liposome-mediated delivery of pteridine antifolates to cells in vitro: potency of methotrexate, and its alpha and gamma substituents.

@article{Heath1986LiposomemediatedDO,
  title={Liposome-mediated delivery of pteridine antifolates to cells in vitro: potency of methotrexate, and its alpha and gamma substituents.},
  author={Timothy D. Heath and N G Lopez and James R Piper and John A. Montgomery and Walter H. Stern and Demetrios Papahadjopoulos},
  journal={Biochimica et biophysica acta},
  year={1986},
  volume={862 1},
  pages={72-80}
}
We have examined the growth-inhibitory potency of several pteridines encapsulated in negatively charged liposomes, including methotrexate, methotrexate-gamma-methylamide, methotrexate-gamma-dimethylamide, methotrexate-alpha-aspartate, and a lipophilic methotrexate-phosphatidylethanolamine conjugate. The potency of encapsulated methotrexate is greater than… CONTINUE READING