Liposome incorporated ion sensitive in situ gels for opthalmic delivery of timolol maleate.

@article{Yu2015LiposomeII,
  title={Liposome incorporated ion sensitive in situ gels for opthalmic delivery of timolol maleate.},
  author={Shihui Yu and Qi-Ming Wang and Xin Wang and Dandan Liu and Wenji Zhang and Tiantian Ye and Xinggang Yang and Weisan Pan},
  journal={International journal of pharmaceutics},
  year={2015},
  volume={480 1-2},
  pages={
          128-36
        }
}
  • Shihui Yu, Qi-Ming Wang, +5 authors Weisan Pan
  • Published in
    International journal of…
    2015
  • Chemistry, Medicine
  • This study was aimed to design a liposomal based ion-sensitive in situ ophthalmic delivery system of timolol maleate (TM). The TM liposome was produced by the reverse evaporation technique coupled with pH-gradients method (REVPR), and then was incorporated into deacetylated gellan gum gels. The TM liposome was demonstrated to be a round and uniform shape in TEM pictures. Compared with the TM eye drops, the TM liposome produced a 1.93 folds increase in apparent permeability coefficients (Papp… CONTINUE READING

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