Liposome formulated with TAT-modified cholesterol for enhancing the brain delivery.

@article{Qin2011LiposomeFW,
  title={Liposome formulated with TAT-modified cholesterol for enhancing the brain delivery.},
  author={Yao Qin and Huali Chen and Wenmin Yuan and Rui Kuai and Qianyu Zhang and Fulan Xie and Li Zhang and Zhirong Zhang and Ji Liu and Qin He},
  journal={International journal of pharmaceutics},
  year={2011},
  volume={419 1-2},
  pages={85-95}
}
Delivery of drugs to the brain is a major challenge due to the presence of the blood-brain barrier (BBB). The cell penetrating peptide TAT, which appears to enter cells with alacrity, can pass through the BBB efficiently. With this in mind, a novel TAT-modified liposome (TAT-LIP) was developed for overcoming the ineffective delivery of normal drug formulation to the brain. Targeting liposomal formulations are always composed of modified phospholipids as an anchor. However, cholesterol, another… CONTINUE READING
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