Liposome-entrapped PGE1 posttreatment decreases IL-1 alpha-induced neutrophil accumulation and lung leak in rats.

@article{Leff1994LiposomeentrappedPP,
  title={Liposome-entrapped PGE1 posttreatment decreases IL-1 alpha-induced neutrophil accumulation and lung leak in rats.},
  author={Jonathan A. Leff and Jeanne W. Baer and J M Kirkman and M E Bodman and Paul F. Shanley and Okyong J. Cho and Marc J. Ostro and John E. Repine},
  journal={Journal of applied physiology},
  year={1994},
  volume={76 1},
  pages={151-7}
}
We found that treatment with liposome-entrapped prostaglandin E1 (Lip-PGE1), but not with empty liposomes and/or free PGE1, decreased the leak of intravascularly administered 125I-labeled albumin into lungs of rats given interleukin-1 alpha (IL-1 alpha) intratracheally. Lip-PGE1 treatment also decreased lung myeloperoxidase activity, lung lavage neutrophil increases, and lung histological abnormalities found in rats given IL-1 alpha intratracheally. Interestingly, decreased lung leak and lung… CONTINUE READING
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