Liposome encapsulation of lipophilic N-alkyl-propanediamine platinum complexes: impact on their cytotoxic activity and influence of the carbon chain length

@inproceedings{Silva2010LiposomeEO,
  title={Liposome encapsulation of lipophilic N-alkyl-propanediamine platinum complexes: impact on their cytotoxic activity and influence of the carbon chain length},
  author={Heveline Silva and Teresa P. Lopes and Fr{\'e}d{\'e}ric Fr{\'e}zard},
  year={2010}
}
Complexos de platina(II) derivados de N-alquil-propanodiamina com cadeia carbonica variavel (C8, C10, C12 ou C14) foram incorporados em lipossomas e a atividade citotoxica dessas formulacoes foi avaliada em linhagens tumorais (A549, MDA-MB-231, B16-F1 and B16-F10) e nao-tumorais (BHK-21 and CHO). Suspensoes de lipossomas estaveis e monodispersas incorporando os complexos de platina foram obtidas com uma composicao lipidica de diestearoil-sn-glicero-3-fosfocolina, colesterol, e 1,2-diestearoil… CONTINUE READING

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