Liposome-encapsulated ursolic acid increases ceramides and collagen in human skin cells

  title={Liposome-encapsulated ursolic acid increases ceramides and collagen in human skin cells},
  author={Dawn M. Both and K. Goodtzova and D. Yarosh and D. Brown},
  journal={Archives of Dermatological Research},
  • Dawn M. Both, K. Goodtzova, +1 author D. Brown
  • Published 2001
  • Medicine, Biology
  • Archives of Dermatological Research
  • Abstract. Skin wrinkling and xerosis associated with aging result from decreases in dermal collagen and stratum corneum ceramide content. This study demonstrated that ursolic acid incorporated into liposomes (URA liposomes) increases both the ceramide content of cultured normal human epidermal keratinocytes (NHEK), and the collagen content of cultured normal human dermal fibroblasts. In addition, URA liposomes increased the ceramide content of the skin of human subjects, with increases in… CONTINUE READING
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