Liposome destabilization induced by the HIV-1 fusion peptide effect of a single amino acid substitution.

@article{Pereira1995LiposomeDI,
  title={Liposome destabilization induced by the HIV-1 fusion peptide effect of a single amino acid substitution.},
  author={Francisca Pereira and F{\'e}lix M Go{\~n}i and Jos{\'e} Luis Nieva},
  journal={FEBS letters},
  year={1995},
  volume={362 2},
  pages={243-6}
}
The 23-residue synthetic peptide representing the N-terminus of HIV-1 gp41 is known to induce either leakage or fusion of lipid vesicles depending on the experimental conditions. In this paper we report that a polar amino acid substitution V-->E at position 2, known to block gp41 activity in vivo, makes the peptide unable to destabilize and/or fuse membranes. Moreover this variant, unlike the parent peptide, is never found in the membrane-associated beta conformation. 

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