• DOI:10.1248/CPB.36.3557
Corpus ID: 24121894

Liposomal sustained-release delivery systems for intravenous injection. II. Design of liposome carriers and blood disposition of lipophilic mitomycin C prodrug-bearing liposomes.

@article{Tokunaga1988LiposomalSD,
  title={Liposomal sustained-release delivery systems for intravenous injection. II. Design of liposome carriers and blood disposition of lipophilic mitomycin C prodrug-bearing liposomes.},
  author={Y. Tokunaga and T. Iwasa and J. Fujisaki and S. Sawai and A. Kagayama},
  journal={Chemical \& pharmaceutical bulletin},
  year={1988},
  volume={36 9},
  pages={
          3557-64
        }
}

• Y. Tokunaga, T. Iwasa, +2 authors A. Kagayama
• Published 1988
• Chemistry, Medicine
• Chemical & pharmaceutical bulletin

Various types of unilamellar liposomes possessing a narrow size distribution were prepared by controlled dialysis and their blood clearance was studied in mice and rats to assess their suitability as drug carriers for intravenously injectable liposomal sustained-release delivery systems. Also, the utility of these liposomal carrier systems combined with lipophilic prodrugs of mitomycin C (MMC) was evaluated. The fate of the liposomes was monitored uisng N-4-nitrobenzo-2-oxa-1, 3-diazole… Expand

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