Liposomal leakage induced by virus-derived peptides, viral proteins, and entire virions: rapid analysis by chip electrophoresis.

@article{Weiss2010LiposomalLI,
  title={Liposomal leakage induced by virus-derived peptides, viral proteins, and entire virions: rapid analysis by chip electrophoresis.},
  author={Victor U Weiss and Gerhard Bilek and Angela Maria Pickl-Herk and Xavier Subirats and Katarzyna Niespodziana and Rudolf Valenta and Dieter Blaas and Ernst Kenndler},
  journal={Analytical chemistry},
  year={2010},
  volume={82 19},
  pages={
          8146-52
        }
}
Permeabilization of model lipid membranes by virus-derived peptides, viral proteins, and entire virions of human rhinovirus was assessed by quantifying the release of a fluorescent dye from liposomes via a novel chip electrophoretic assay. Liposomal leakage readily occurred upon incubation with the pH-sensitive synthetic fusogenic peptide GALA and, less efficiently, with a 24mer peptide (P1-N) derived from the N-terminus of the capsid protein VP1 of human rhinovirus 2 (HRV2) at acidic pH… CONTINUE READING
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