Liposomal entrapment of the neutrophil-derived peptide indolicidin endows it with in vivo antifungal activity.

@article{Ahmad1995LiposomalEO,
  title={Liposomal entrapment of the neutrophil-derived peptide indolicidin endows it with in vivo antifungal activity.},
  author={Imran Ahmad and Walter R. Perkins and David M. Lupan and Michael E Selsted and Andrew S. Janoff},
  journal={Biochimica et biophysica acta},
  year={1995},
  volume={1237 2},
  pages={
          109-14
        }
}
Indolicidin, a cationic tridecapeptide amide isolated from the granules of bovine neutrophils, has been found to possess potent antimicrobial activity in vitro but its nonselective toxicity could restrict its therapeutic utility. We found that the concentration at which indolicidin disrupts washed human red blood cell membranes coincided with the concentration at which indolicidin self associates. Because of a preponderance of hydrophobic residues, we believed that indolicidin would partition… CONTINUE READING
Highly Cited
This paper has 64 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

Microencapsulation of LL 37 Antimicrobial Peptide in PLGA

Sarah El Abbouni
2016
View 5 Excerpts
Highly Influenced

MODE OF ACTION OF ANTIMICROBIAL PEPTIDES

View 6 Excerpts
Highly Influenced

Improved activity of a synthetic indolicidin analog.

Antimicrobial agents and chemotherapy • 1997
View 4 Excerpts
Highly Influenced

65 Citations

0510'96'01'07'13'19
Citations per Year
Semantic Scholar estimates that this publication has 65 citations based on the available data.

See our FAQ for additional information.