Liposomal encapsulation of glucocorticoids alters their mode of action in the treatment of experimental autoimmune encephalomyelitis.

@article{Schweingruber2011LiposomalEO,
  title={Liposomal encapsulation of glucocorticoids alters their mode of action in the treatment of experimental autoimmune encephalomyelitis.},
  author={Nils Schweingruber and Axel Haine and Karsten Tiede and Anna Karabinskaya and Jens van den Brandt and Simone W{\"u}st and Josbert M. Metselaar and Ralf Gold and Jan P Tuckermann and Holger M. Reichardt and Fred L{\"u}hder},
  journal={Journal of immunology},
  year={2011},
  volume={187 8},
  pages={4310-8}
}
Glucocorticoids (GCs) are widely used to treat acute relapses of multiple sclerosis (MS). In this study, we demonstrate that liposomal encapsulation augments the therapeutic potency of GCs as they ameliorate experimental autoimmune encephalomyelitis (EAE) to the same extent as free GC, but at strongly reduced dosage and application frequency. Importantly, this is accompanied by an altered mode of action. Unlike free GCs, which mainly target T lymphocytes during EAE therapy, liposomal GCs only… CONTINUE READING

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