Liposomal drug formulations in the treatment of rheumatoid arthritis.

  title={Liposomal drug formulations in the treatment of rheumatoid arthritis.},
  author={Jolanda M van den Hoven and Sophie R Van Tomme and Josbert M. Metselaar and Bastiaan Nuijen and Jos H. Beijnen and Gert Storm},
  journal={Molecular pharmaceutics},
  volume={8 4},
Liposomes have been extensively investigated as drug delivery systems in the treatment of rheumatoid arthritis (RA). Low bioavailability, high clearance rates and limited selectivity of several important drugs used for RA treatment require high and frequent dosing to achieve sufficient therapeutic efficacy. However, high doses also increase the risk for systemic side effects. The use of liposomes as drug carriers may increase the therapeutic index of these antirheumatic drugs. Liposomal… CONTINUE READING