Liposomal drug delivery systems: from concept to clinical applications.

  title={Liposomal drug delivery systems: from concept to clinical applications.},
  author={Theresa M. Allen and Pieter R Cullis},
  journal={Advanced drug delivery reviews},
  volume={65 1},
The first closed bilayer phospholipid systems, called liposomes, were described in 1965 and soon were proposed as drug delivery systems. The pioneering work of countless liposome researchers over almost 5 decades led to the development of important technical advances such as remote drug loading, extrusion for homogeneous size, long-circulating (PEGylated) liposomes, triggered release liposomes, liposomes containing nucleic acid polymers, ligand-targeted liposomes and liposomes containing… CONTINUE READING
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