Liposomal clodronate inhibition of osteoclastogenesis and osteoinduction by submicrostructured beta-tricalcium phosphate.

@article{Davison2014LiposomalCI,
  title={Liposomal clodronate inhibition of osteoclastogenesis and osteoinduction by submicrostructured beta-tricalcium phosphate.},
  author={Noel L. Davison and Anne-laure Gamblin and P. Layrolle and H. Yuan and Joost D. de Bruijn and F. Barr{\`e}re-de Groot},
  journal={Biomaterials},
  year={2014},
  volume={35 19},
  pages={
          5088-97
        }
}
  • Noel L. Davison, Anne-laure Gamblin, +3 authors F. Barrère-de Groot
  • Published 2014
  • Medicine, Materials Science
  • Biomaterials
  • Bone graft substitutes such as calcium phosphates are subject to the innate inflammatory reaction, which may bear important consequences for bone regeneration. We speculate that the surface architecture of osteoinductive β-tricalcium phosphate (TCP) stimulates the differentiation of invading monocyte/macrophages into osteoclasts, and that these cells may be essential to ectopic bone formation. To test this, porous TCP cubes with either submicron-scale surface architecture known to induce… CONTINUE READING
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