Liposomal clodronate inhibition of osteoclastogenesis and osteoinduction by submicrostructured beta-tricalcium phosphate.

@article{Davison2014LiposomalCI,
  title={Liposomal clodronate inhibition of osteoclastogenesis and osteoinduction by submicrostructured beta-tricalcium phosphate.},
  author={Noel L. Davison and Anne-laure Gamblin and Pierre Layrolle and Huipin Yuan and Joost D. de Bruijn and Florence Y F Barr{\`e}re-de Groot},
  journal={Biomaterials},
  year={2014},
  volume={35 19},
  pages={5088-97}
}
Bone graft substitutes such as calcium phosphates are subject to the innate inflammatory reaction, which may bear important consequences for bone regeneration. We speculate that the surface architecture of osteoinductive β-tricalcium phosphate (TCP) stimulates the differentiation of invading monocyte/macrophages into osteoclasts, and that these cells may be essential to ectopic bone formation. To test this, porous TCP cubes with either submicron-scale surface architecture known to induce… CONTINUE READING
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  • AMC Barradas, H Yuan, J van der Stok, B Le Quang, H Fernandes, A Chaterjea
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