Liposomal clodronate as a novel agent for treating autoimmune hemolytic anemia in a mouse model.

@article{Jordan2003LiposomalCA,
  title={Liposomal clodronate as a novel agent for treating autoimmune hemolytic anemia in a mouse model.},
  author={Michael B. Jordan and Nico Van Rooijen and Shozo Izui and John Kappler and Philippa Marrack},
  journal={Blood},
  year={2003},
  volume={101 2},
  pages={594-601}
}
Autoimmune hemolytic anemia (AIHA) is a disease in which autoantibodies against red blood cells (RBCs) lead to their premature destruction. Most clinically significant autoantibodies are of the immunoglobulin G (IgG) type, which leads primarily to the uptake and destruction of RBCs by splenic and hepatic macrophages. Therapies such as corticosteroids and splenectomy are directed at interfering with this process. Liposomally encapsulated clodronate (dichloromethylene diphosphonate) has… CONTINUE READING
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