Lipoproteins inhibit macrophage activation by lipoteichoic acid.

@article{Grunfeld1999LipoproteinsIM,
  title={Lipoproteins inhibit macrophage activation by lipoteichoic acid.},
  author={Carl Grunfeld and Monique Marshall and Judy K. Shigenaga and Arthur H. Moser and Paris Tobias and Kennenth R Feingold},
  journal={Journal of lipid research},
  year={1999},
  volume={40 2},
  pages={245-52}
}
Regulation of lipid metabolism during infection is thought to be part of host defense, as lipoproteins neutralize endotoxin (LPS) and viruses. Gram-positive infections also induce disturbances in lipid metabolism. Therefore, we investigated whether lipoproteins could inhibit the toxic effects of lipoteichoic acid (LTA), a fragment of gram-positive bacteria. LTA activated RAW264.7 macrophage cells, stimulating production of tumor necrosis factor (TNF) in a dose-dependent matter, but produced… CONTINUE READING
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