Lipoprotein lipase gene mutations, plasma lipid levels, progression/regression of coronary atherosclerosis, response to therapy, and future clinical events. Lipoproteins and Coronary Atherosclerosis Study.

@article{Sing1999LipoproteinLG,
  title={Lipoprotein lipase gene mutations, plasma lipid levels, progression/regression of coronary atherosclerosis, response to therapy, and future clinical events. Lipoproteins and Coronary Atherosclerosis Study.},
  author={Kimberly Anne Sing and Christie M. Ballantyne and Laura Ferlic and Ramon Brugada and Ian Cushman and John K. Dunn and J. Alan Herd and Henry J. Pownall and Antonio M. Gotto and Ali J Marian},
  journal={Atherosclerosis},
  year={1999},
  volume={144 2},
  pages={435-42}
}
Mutations in human lipoprotein lipase (LPL) gene are potential risk factors for susceptibility to coronary artery disease (CAD). The objectives of this study were to determine the influence LPL mutations Asn291Ser and Ser447Ter on plasma lipid levels, regression and progression of CAD, clinical events rate, and response to fluvastatin therapy in the Lipoprotein and Coronary Atherosclerosis Study (LCAS) population. LCAS is a double blind, randomized, placebo-controlled study designed to test the… CONTINUE READING

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