Lipoprotein lipase expression level influences tissue clearance of chylomicron retinyl ester.

  title={Lipoprotein lipase expression level influences tissue clearance of chylomicron retinyl ester.},
  author={Ari{\"e}tte M van Bennekum and Yuko Kako and P H Weinstock and Earl H. Harrison and Richard J. Deckelbaum and Ira J Goldberg and William S. Blaner},
  journal={Journal of lipid research},
  volume={40 3},
Approximately 25% of postprandial retinoid is cleared from the circulation by extrahepatic tissues. Little is known about physiologic factors important to this uptake. We hypothesized that lipoprotein lipase (LpL) contributes to extrahepatic clearance of chylomicron vitamin A. To investigate this, [3H]retinyl ester-containing rat mesenteric chylomicrons were injected intravenously into induced mutant mice and nutritionally manipulated rats. The tissue sites of uptake of 3H label by wild type… CONTINUE READING


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