Lipoprotein lipase expression is a novel prognostic factor in B-cell chronic lymphocytic leukemia

@article{Nuckel2006LipoproteinLE,
  title={Lipoprotein lipase expression is a novel prognostic factor in B-cell chronic lymphocytic leukemia},
  author={Holger Nückel and Andreas H{\"u}ttmann and Ludger Klein-Hitpass and Roland Schroers and Anja Führer and Ludger Sellmann and Ulrich D{\"u}hrsen and Jan D{\"u}rig},
  journal={Leukemia \& Lymphoma},
  year={2006},
  volume={47},
  pages={1053 - 1061}
}
B-cell chronic lymphocytic leukemia (B-CLL) is a heterogenous disease with a highly variable clinical course. Recent studies have shown that expression of lipoprotein lipase (LPL) and ADAM29 may serve as novel prognostic markers in B-CLL. To investigate the prognostic value of these genes, we quantified their expression in peripheral blood mononuclear cells using quantitative reverse transcriptase-polymerase chain reaction (RQ-PCR) in a cohort of 133 B-CLL patients and correlated the results… 
Lipoprotein lipase: a new prognostic factor in chronic lymphocytic leukaemia
TLDR
LPL mRNA expression level was able to predict mutational status in a high percentage of CLL cases and high LPL expression was associated with shorter treatment-free survival, and since LPL activity is low (or absent), its expression can be determined by PCR technique in peripheral blood mononuclear cells or in lysed blood samples.
Prognostic value of lipoprotein lipase expression among egyptian B-chronic lymphocytic leukemia patients.
TLDR
LPL expression can serve as a new surrogate prognostic factor for CLL patients and can be used to detect patients who need early treatment, demonstrated statistically significant association between high level of LPL expression and significantly high LDH level, poor cytogenetic risk, ZAP- 70 expression and response to therapy.
Lipoprotein Lipase as a Prognostic Marker in Chronic Lymphocytic Leukemia
TLDR
The results confirm that LPL is a strong predictor of outcome in CLL, able to improve prognostic accuracy in good risk cytogenetic subgroups and the relationship between its prognostic and functional role in C LL needs to be explored further.
Lipoprotein lipase in chronic lymphocytic leukemia: function and prognostic implications
TLDR
Current knowledge on the prognostic and biological relevance of LPL in CLL is reviewed, finding that LPL exerts a central role in overall lipid metabolism and transport, but plays additional, non‐catalytic roles as well.
Expression level of lipoprotein lipase in Chinese patients with chronic lymphocytic leukemia and its correlation with other prognostic factors
TLDR
It was showed that LPL expression correlates with IgVH mutational status and other clinical or laboratory prognostic factors, and might be applied for the assessment of prognosis in patients with CLL.
Expression level of lipoprotein lipase and dystrophin genes predict survival in B-cell chronic lymphocytic leukemia
Mutational status of immunoglobulin variable region genes (VH-genes) is known as the strongest predictor of long term prognosis in B-CLL. However, applications in the routine clinical practice are
High CD49d protein and mRNA expression predicts poor outcome in chronic lymphocytic leukemia.
TLDR
The data confirm the prognostic significance supporting the idea to use CD49d as target molecules for therapeutic approaches in B-CLL and the results on mRNA level with worse prognosis for patients with high mRNA level are confirmed.
Expression of Bcl2L12 in chronic lymphocytic leukemia patients: association with clinical and molecular prognostic markers
TLDR
Quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) analysis revealed a significant overexpression of Bcl2L12 mRNA in CLL samples compared to non-leukemic samples, implying its role in the pathogenesis of the disease.
Gene expression signatures separate B-cell chronic lymphocytic leukaemia prognostic subgroups defined by ZAP-70 and CD38 expression status
TLDR
Three genes, that is, immune receptor translocation-associated protein 4 (IRTA4)/Fc receptor homologue 2 (FcRH2), angiopoietin 2 (ANGPT2) and Pim2 were selected for further validating studies in a cohort of 94 B-CLL patients.
Progranulin Is a Novel Independent Predictor of Disease Progression and Overall Survival in Chronic Lymphocytic Leukemia
TLDR
It is found that high Pgrn plasma levels were strongly associated with adverse risk factors including unmutated IGHV status, expression of CD38 and ZAP-70, poor risk cytogenetics as detected by flourescence in situ hybridization (FISH) and high Binet stage.
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