Lipoprotein lipase activator ameliorates the severity of dietary steatohepatitis.

  title={Lipoprotein lipase activator ameliorates the severity of dietary steatohepatitis.},
  author={Jun Yu and Eagle Siu Hong Chu and Alex Yui Hui and K. F. Cheung and Henry L. Y. Chan and Wai Keung Leung and Geoffrey C. Farrell and Joseph Jao Yiu Sung},
  journal={Biochemical and biophysical research communications},
  volume={356 1},
Dietary model of steatohepatitis was established by feeding mice a methionine choline deficient (MCD) diet. Mice on MCD or control diet for 3 weeks were treated with or without NO-1886, a newly synthetic lipoprotein lipase (LPL) activator. In a separate experiment, NO-1886 was given after pre-treatment with 3 weeks of MCD diet. NO-1886 significantly reduced MCD-induced inflammation by repressing levels of hepatic lipid peroxides and pro-inflammatory tumor necrosis factor-alpha (TNF-alpha… CONTINUE READING