Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy.

  title={Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy.},
  author={Hiroaki Yagyu and Guangping Chen and Masayoshi Yokoyama and Kumiko Hirata and Ayanna S. Augustus and Yuko Kako and Toru Seo and Yunying Hu and Elisabeth Lutz and Martin Merkel and Andr{\'e} Bensadoun and Shunichi Homma and Ira J Goldberg},
  journal={The Journal of clinical investigation},
  volume={111 3},
Lipoprotein lipase is the principal enzyme that hydrolyzes circulating triglycerides and liberates free fatty acids that can be used as energy by cardiac muscle. Although lipoprotein lipase is expressed by and is found on the surface of cardiomyocytes, its transfer to the luminal surface of endothelial cells is thought to be required for lipoprotein lipase actions. To study whether nontransferable lipoprotein lipase has physiological actions, we placed an alpha-myosin heavy-chain promoter… CONTINUE READING


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