Lipoprotein lipase: structure, function, regulation, and role in disease

@article{Mead2002LipoproteinLS,
  title={Lipoprotein lipase: structure, function, regulation, and role in disease},
  author={James R. Mead and Scott Alexander Irvine and Dipak P. Ramji},
  journal={Journal of Molecular Medicine},
  year={2002},
  volume={80},
  pages={753-769}
}
Abstract. Lipoprotein lipase (LPL) catalyses the hydrolysis of the triacylglycerol component of circulating chylomicrons and very low density lipoproteins, thereby providing non-esterified fatty acids and 2-monoacylglycerol for tissue utilisation. Research carried out over the past two decades have not only established a central role for LPL in the overall lipid metabolism and transport but have also identified additional, non-catalytic functions of the enzyme. Furthermore, abnormalities in LPL… 
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The role of LPL in atherosclerosis, and its regulation by mediators that are known to be present in the lesion are dealt with.
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Lipoprotein lipase (LPL) plays a crucial role in lipid metabolism by catalysing the hydrolysis of the triacylglycerol core of chylomicrons and very low density lipoproteins (VLDL), thereby providing
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