Lipoprotein-incorporated pregnenolone fatty acid esters act as substrate for ovarian progestin synthesis.

@article{Roy1991LipoproteinincorporatedPF,
  title={Lipoprotein-incorporated pregnenolone fatty acid esters act as substrate for ovarian progestin synthesis.},
  author={Robert J. Le Roy and Alain B{\'e}langer},
  journal={Biochemical and biophysical research communications},
  year={1991},
  volume={179 3},
  pages={
          1576-81
        }
}
Progesterone is of great importance in the normal development of the ovarian follicle and its biosynthesis has been shown to rely on plasma low-density lipoproteins for delivery of cholesterol substrate. However, the pre-ovulatory ovarian follicle has no access to plasma low-density lipoproteins suggesting that other substrates may be involved in pre-ovulatory progestin production. We show in this study using tritiated pregnenolone fatty acid esters incorporated into lipoproteins can give rise… CONTINUE READING