Lipoprotein-associated phospholipase A2 mass and activity in children with heterozygous familial hypercholesterolemia and unaffected siblings: effect of pravastatin.

@article{Ryu2011LipoproteinassociatedPA,
  title={Lipoprotein-associated phospholipase A2 mass and activity in children with heterozygous familial hypercholesterolemia and unaffected siblings: effect of pravastatin.},
  author={Sung Kee Ryu and Barbara A. Hutten and Maud N. Vissers and Albert Wiegman and John J. P. Kastelein and Sotirios Tsimikas},
  journal={Journal of clinical lipidology},
  year={2011},
  volume={5 1},
  pages={50-6}
}
BACKGROUND Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an independent risk factor of cardiovascular disease and a target of treatment. Lp-PLA(2) levels in children have not been previously reported. The effect of statin therapy on Lp-PLA(2) mass and activity in children with familial hypercholesterolemia (FH) is also not known. METHODS Lp-PLA(2) mass and activity levels were measured at baseline and after 2 years in 178 children with FH randomized to pravastatin or placebo and in… CONTINUE READING

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