Lipoprotein-associated phospholipase A2: a target directed at the atherosclerotic plaque.

@article{Suckling2002LipoproteinassociatedPA,
  title={Lipoprotein-associated phospholipase A2: a target directed at the atherosclerotic plaque.},
  author={Keith E. Suckling and Colin H. Macphee},
  journal={Expert opinion on therapeutic targets},
  year={2002},
  volume={6 3},
  pages={309-14}
}
Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is so named because it is found in human plasma largely associated with low-density lipoprotein (LDL). It is secreted by macrophages and able to hydrolyse oxidised fatty acids from oxidised phospholipids in LDL thereby releasing pro-atherogenic lysophosphatidylcholine and fatty acids. Inhibition of this enzyme activity was proposed to be antiatherogenic and this hypothesis has been confirmed both in vitro and in animal studies using specific… CONTINUE READING